US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida
Throughout the last century, numerous studies have investigated the effects of bladder reinnervation using somatic-autonomic nerve cross union in both animals and humans. In 1967, Carlsson and Sundin detailed a case involving a four-year-old spina bifida patient who underwent motor root rerouting, leading to reflex micturition and bladder sensation after eight months of recovery. While initial interest in nerve rerouting existed, Xiao and Godec further explored this concept through animal studies confirming bladder reinnervation and reflex micturition. Subsequent reports indicated early clinical success in humans with spina bifida.
Understanding the clinical significance of demonstrating a cutaneous-to-bladder reflex on UDS is challenging. At one year, eight of thirteen subjects had a reproducible reflex. Although this reflex provided some evidence of bladder reinnervation, its presence did not always align with the clinical response. By three years, this reflex was only evident in two patients, yet most, including these two, could void efficiently using some degree of Valsalva. Comprehending the emergence and apparent suppression of this reflex over time is complex. It is possible that the bladder is no longer innervated by the somatic nerve, which seems unlikely given the clinical improvements, or the reflex becomes suppressed. Over time, there may be a reconfiguration of the micturition centers in the brain, and as the child learns to void independently, the brain suppresses this reflex, as observed in toilet training. It would be intriguing to conduct functional magnetic resonance imaging (fMRI) of the brain before and after nerve rerouting to observe the effects of stimulating this reflex compared to patients who regain sensation and can void without reflex stimulation. Additionally, it would be interesting to explore the relationships between cutaneous stimulation, rectal activity, improved bladder sensation, and the emergence/disappearance of the skin-bladder reflex.
In conclusion, this pilot trial demonstrated improvements in bladder and bowel function in spina bifida patients following lumbar to sacral nerve rerouting. Future studies should expand on these findings, ensuring patient consent and understanding of potential outcomes, including the risk of permanent foot drop. While further data are necessary to fully comprehend the procedure’s impact, nerve rerouting shows promise in revolutionizing the management of neurogenic bladder in patients.